Kind of subjective. The same things that make it easier to shoot with two hands apply for one hand.
The heavier the better, up till it is no longer comfortable to hold.
The lighter cartridge the better, as long as it's powerful enough for the task.
Depending on barrel length I'm comfortable with a gun that weighs about 45oz. There aren't many normal cartridges that will require two hands with a gun that heavy.
A 6" S&W M-617 hardly moves with standard .22lr rounds.
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