H380 is my go to powder for .30-06 and .270. I have worked some exceptional sub MOA loads with it. My go to .30-06 is a Hornady 165 grn SST bullet with 54.5 grains of H380 and CCI 250 primers. I can put five rounds in the size of a quarter with this load.
I have a killer .270 110 grain bullet load that just drops whitetail like crazy. I have yet to work up a better load than the factory 130 SST Hornady factory load, so I quit trying.