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I personally killed 8 1,000 lb steers with .22 LR in preparation for slaughter. They all fell to the shot (brain of course) but lived long enough for the throat to be cut and thus all the blood pumped out before actually expiring. I realize the blood loss was probably the actual cause of death but I was amazed at how effective that little 22 rimfire was in incapacitating those large cattle.
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