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- is more expensive, so I can shoot it less
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Economics, me thinks, is the limiting factor. Newly introduced handgun cartridges are more expensive than established; new shooters will exclude the new ammo because of the cost; high-volume recreational shooters (formerly me) will also; occasional budget shooters (like me) certainly will not buy a novelty round; manufactures hesitate to introduce guns for new cartridges because they will not sell initially. A huge chunk of the consumer market is priced out thus a new and expensive niche cartridge is destined from the start to become an permanent and expensive niche cartridge. So, why try to make a new handgun cartridge?
Glock still has .45 GAP advertised on their website. Did anyone else make a pistol for .45 GAP? Is Sig giving up on .357 SIG? The P226, their flagship pistol, has 4 options listed on the website, all 9mm. .357 is mentioned as an option at the bottom of the page.