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I'm not sure the LCR could handle the pressures of the .327.
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There's one in .357, so I don't see an issue. The .327 would be a neat match for that gun.
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One of the unique calibers I have a hard time defending is the .41.
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I don't. Out of a S&W N-Frame, it's got a healthy but manageable amount of recoil, and it's not as loud as .44 Magnum. Most factory loads are very accurate, and handloaders can do some neat things with it.
It's very rare for cartridges to just
die. I still have folks asking for .38 S&W and .32 S&W Long enough to keep those loads in stock. As long as there are guns, there will be demand for the ammunition.