I haven't read all the responses real closely, but along with the many things already mentioned, with 44 Mag, you generally use slower powders.
Speaking for myself, the only powder I use (virtually) for 44 Magnum is Winchester 296 (also sold as Hodgdon H110). W296 is a ball powder that is difficult to ignite. I always use magnum primers (CCI 350) and a generous roll crimp. All other above-mentioned important factors aside, the load itself requires a hearty crimp.
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