I have found that the rapid expanding type of bullets, placed behind the shoulder of a whitetail buck lay it right down. The same bullet placed in the shoulder make a big mess of that shoulder. However three quarters of a deer beats no deer every time.
I have a 25-06 that is used with 100 gr Barnes-X handloads at around 3300fps that is rather lethal and meat damage is minimal, even when shot in a ham. Did that once and don't recommend it, but it beats a gut shot. Been there and done that, too.
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Use enough gun.
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