The advantage of a larger caliber over a smaller one on the same case is bullet weight! In the 30-06 case, the 30-06 tops out at 225gr and the 338 at 250grs. I don't recall seeing 225gr bullet's very much for the 30 cal but 250 for a 338 cal are pretty common. Years ago Speer made a 275 gr 338 bullet. Don't know if they make it anymore.
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