[thedudeabides]

SP2022

Pros:
Real hammer and DA/SA trigger with great crisp SA pull
"compact" but on the bigger side of compact
Comes with night sights
Replacable backstrap for different hand sizes

Cons:
Only 9mm and 40 SW
Comes only in one size

P250

Pros:
Comes in every single damn caliber Sigs can shoot
Comes in every size, from subcompact to full size
Night sights? Sure, Sig puts those on everything from keychains to socks

Cons:
Trigger sucks. If you want a DAO-ish plastic gun, get a Glock, or a Shield, or an XD--they get it better
Caliber X-change kits are hard to find, expensive, and despite their claim as a "one stop modular weapons platform for every caliber" it's usually cheaper to buy another P250

My advice? Get a SP2022... or get a used P229 (used P226s are hard to find since cops use the P229). The P229 destroys the plastic Sigs in terms of accuracy and quality... Or a full-size P250 in 45 ACP (it's the least offensive). But I don't think Sig got it right with the P250.