I have several calibers to choose from to use, 30-06, 8mm, 243, 7.62x39 and 280, I've killed deer with all of them.
The 280 is by far my favorite.
I've also killed deer with pistols 357mag and 45acp.
I've pretty much lost interest in deer hunting, did not go last year and I don't plan on going this year.
Best Regards
Bob Hunter
www.huntercustoms.com