Unless the animal is standing pretty much broadside to the shooter, there is going to be some shoulder damage from a properly placed shot thru the boiler room. Quartering towards the shooter, the near shoulder gets hit. Quartering away the far shoulder. This is getting over thought IMO. The amount of meat in the ribs and shoulders is pretty minimal (like Zerojunk said.)
Ballistic Tips are excellent as are Core lokt IMO. Open up at all reasonable velocities and the energy is expended in the animal. 150 gr would work great. There are stories about all bullets that have failed to open up or exploded on impact or whatever. I have learned to ignore those---most of the time.
