Where I've seen this issue discussed in the past, the usual argument against using reloads is that a wily prosecutor will claim that factory ammunition wasn't deadly enough for the defendant, so he made his own "super powerful, kills on contact ammunition." I've always thought that a reasonably competent defense lawyer could blow holes in this argument pretty easily. Where the use of reloads might be an issue is where the defendant's guilt or innocence is somehow predicated on the distance at which the shot was fired. Testing another round out of the box used by the defendant might be determinative of the distance at which the shot was fired, by studying powder dispersion patterns. Even this won't necessarily be dispositive, since an element of randomness is going to be present and the dispersion pattern won't be exactly alike even from the same box of cartridges.
In short, it's probably a good idea to carry factory ammo just so a prosecutor can't go down that particular rabbit trail, but I wouldn't hesitate to load up with reloads if that's all I had.
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“You may all go to hell and I will go to Texas.” – David Crockett
“If I owned Texas and hell, I'd rent out Texas and live in hell.” - General Phillip H. Sheridan
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