Have you fired the two calibers side-by-side to see how they handle?
I have no experience with either of the two models you're considering, but I'd take an extra round of .40 over the extra size (and recoil, and expense) of .45 any day.
I always assumed that being in a wheelchair would allow you to carry a larger gun than normal. Concealed in a fanny-pack on the armrest or something.
Ivan
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