Pyrodex is a strange powder. In some of the chronographed results I see that Pyrodex produces velocities similar to Swiss. But then in some others it's more like standard Goex.
Omnivore tested his 100 grn .36 cal conicals using 21 grns of 3F Swiss and got an averaged 936 fps with his conical. With the same charge and a .380" ball he got an averaged velocity of 978 fps. With the conical that's right in .380 ACP territory with 195 ft/lbs of energy.
With T7 he got 1127 fps but had a very wide extreme spread eventually (had been doing well until one chamber blew that out the window).
Oh, and apparently I recalled it wrong. This is with his '61 Navy but using a powder charge about what the max is for the Uberti Police. Doubtful the max charge would be all that accurate but then I'd want the shorter 4.5" barrel anyway. I do fancy the longer barrels though...
This is his bullet:
http://www.accuratemolds.com/bullet_...=38-100C-D.png