Before you change the sights have some other people shoot it - or better yet shoot it from a rest.. Low and to the left is pretty a pretty common shooter error to have with .45. If you're unconsciously squeezing the gun a little harder as you pull the trigger in anticipation of the recoil you'll get groups that are low and to the left.
I had exactly the same issue with my 1911. I wound up having to do a lot of practice with longer DA triggers (and a whole lot of dry firing) to get over it. Something about the super short trigger travel seemed to make it harder for me to get over that particular issue.
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