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Pressure is ultimately what determines if a chamber is going to hold up to a particular cartridge. Two bullets can have the same ME, one with a broad, flat lower pressure curve and one with a narrow pressure spike, the latter of which might not be contained by the chamber. Fast powders like Bullseye tend to spike the pressure for a short period of time and are usually reserved for light target loads with small amounts of powder, whereas slower powders like Unique burn slower and apply their pressure over a longer period of time, resulting in somewhat greater muzzle velocity and ME (depending on how much powder is used, of course).
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