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I've seen #4 birdshot penetrate the ribcage of a smallish deer at 15 yards+/- some of it under the opposite side skin and a few totally. I've also seen a load of #6 blow through the skull of a cow at close range. At across the room distance any shotload over 20 guage will devastate the target unless it's wearing a flakvest.
I don't know if any of the worthy advisors have actually used a shotgun up close but I have a few times.
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