The .45 Colt is a reloader's cartridge ... Even the .454 is as well for economy. So if you don't reload, those calibers are out. .44Mag/44Spec is expensive if you don't reload but our more available on the shelf (well, not currently but usually!!!) . Now I reload, and I still don't like to expend 100s of rounds of .45 Colt on just cans in a session. That's where the o' reliable .22 comes in. Expending 200-500 rounds at a time is no biggie and good practice. Really you need (at least) TWO revolvers. One for small game and plinking (camp/range/gopher gun) and other for defense and larger game (your range/hiking/fishing/camping/backup gun). If you are restricted to one gun either the .22 or .357 will work... but you are compromising either way. Of course it should be a Ruger Single Action
Hah! (personal preference).
Oh for a 'general' purpose revolver the barrel length should be at least 4 5/8". Shorties (2"-3") are fine for close work and concealment, but not for target shooting or varminting in 'general'. My preference is 5 1/2" as a good compromise.