I have a very early 550, predates the 650 but have seen one run and like it. Can't comment on it so will comment only on the 550 but suspect the 650 is similar. Caliber changes can be very rapid but that depends on whether it involves a shell plate and/or change in primer size. Caliber changes are also a bit speedier if one has a seperate powder measure for each caliber. I also do a thorough cleaning when I change calibers so that slows it down a bit as well. I don't enjoy loading pistol ammo and the 550 is the best alternative I have to buying cheap ammo-whatever that is.
Some folks have a rounds-fired threshold for buying a progressive. Mine wasn't that complicated. When time spent at the press cut into my time on the range it was time for a Dillon.