The possiblity of things going bad goes up the more you deviate from the standard shot. I would not hesitate to take the shot you described in the OP from a tree stand - it was still a heart/lung shot, just from a higher angle. I have shot deer that were dramatically up hill from me the same way.
I know a guy who has killed more elk with a bow than I ever will. In his "younger" days, he took a good bull with a Texas heart shot. Even though it killed the bull, he says it was the stupidest thing he has ever done hunting. The chances of wounding it and never recovering it were way more than the chances of it being successful.
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It has come with thousands of shots, in every sort of shot angle imaginable. I've practiced and practiced, and studied a deer's anatomy.
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And that is what it really comes down to.