Take a look at the ruger 22/45. Having 3 ladies (wife and two daughters) I would highly recommend starting her off with a 22. She can shoot and shoot and hopefully really enjoy the experence. Then, after she gets hooked introduce her to larger handguns. For me, the last thing I would do is stick a 45 in her hands, scare the crap out of her and loose a shooting partner who otherwise might have wanted to buy more guns....
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