With a .50 caliber in-line Thompson System One muzzle loader, I used 120 grains Pyrodex and a saboted .44 caliber hollow point handgun bullet. Beyond 50 yards I never got an exit on average to large sized deer, but did on smaller deer. On one of the larger bucks it was a well placed shot, the heart literally exploded and he dropped straight down without so much as a twitch. The bullets always expanded to about twice the caliber size, and did a lot of internal damage.
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