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Yours is the original Vaquero made on the regular size Blackhawk size frame. It should be fairly comfortable to shoot with any 38 Special or 357 Mag load. I've shot several different 357 loads in a New Vaquero using HS-6, IMR4227, and Accurate #9. That particular gun seems to shoot closer to point of aim with 158gr bullets. You'll just need to find out what works well for you in yours.
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