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Mechanically, the things that quickly kill or disable are...
-Trauma to a critical juncture of the central nervous system (brain, spine, etc)
-Cessation of blood circulation (either from blood loss, or damage to the heart)
-Critical structural damage (broken bones no longer supporting the body)
beyond that folks have a WIDE range of psychological responses but you can't count on that happening or even what will happen if you miss all of the "big three" above.
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"The dogs may bark but the caravan moves on"
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