Ricciardelli, I have tried shooting left handed - results vary from terrible to just downright awful!
Its not really that bad, but shooting LH with revolvers is much harder for me than semi-autos.
Reloader, good info on 231 and 205gr bullet. Talked to one of the techs at Sierra y'day and he recommended 6.0grs of W231 with a 200gr RNFP bullet. Looks like I've found a great starting point.
Thanks for the input everyone!