Nail polish will come off sometimes in the chamber. George & Roy's won't, at least it hasn't yet.
I've used nail polish in the past and it comes off, especially with hot loads that will cause any movement in the primer, like starting to flow. George & Roy's seems to stick to metal better.
You don't want an AR15 Bolt, magazine and chamber area full of little red rings that came off when the rounds were fired.
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