I've seen what they do on small game from a handgun and it is impressive. They have the same energy as a 38 special. My brother shot a jackrabbit up close with one and blew its whole chest cavity open. It also leave big holes in armadillo even at fair ranges.
For a backup, if rimfire rounds were more reliable, I'd rather have a 22mag than a 32acp.
Also, lookup the Strassburg Goat tests where large goats were shot with different rounds. They stopped testing the 22lr quickly as it wasn't always lethal but the testers noted that the 22mag was surprisingly effective and lethal.
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