The silencer is designed for the specific round. In general, you can shoot a round that has the same diameter and equal or lower pressure through a silencer designed for the higher pressure round. You cannot safely fire a .223 round through a silencer designed for a 22lr. It will come apart. As another poster has pointed out, it is safe to fire a 22lr through a can designed for .223 or 9mm or etc. However, I would not since the .22lr is a very dirty round that will deposit lead in your suppressor.
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"A man's gotta do what he thinks is best."
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