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It's the wrong question.
It's actually a question of sight radius, how well does the grip fit your hands, how easy is the trigger, how well does that load work with that gun, and how much does that caliber recoil for you.
If you put a whatever caliber with whatever sights and grip with a 2" barrel in a padded vice and work on different cartridge loads, eventually you will be getting small groups at 100 yards.
The rest is all about the ability of the shooter.
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