In terms of self defense and concealed carry, I wonder just what the advantages would be of a .45 Colt over a .357 or .38+P.
Before anyone jumps on me, I've been loading .45 Colt since 1983 and have had an assortment of N-frame Smiths (the Model 25-5 and the Mountain Gun).
I can tell you that something like the .45 Colt Silver Tip is a real rip=roarer and makes me think I'd rather handle an N-frame .357 or L-frame with short barrel.
Ditto when it comes to the .44 Special of which I've had a number of Model 24s in years past.
The five-shooters in any caliber or frame size just don't appeal to me.
Now a Pro Shop 8-shooter .357 snubbie could make me look twice. Maybe if I write Clint Eastwood, he could send me the one he used in "Blood Work."