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Suppressors produce back-pressure
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So imagine this...
http://en.wikipedia.org/wiki/File:Magnum44_900pix.jpg
...with the added back pressure of a suppressor. It's not going to be very efficient and reducing the sound of the shot.
That's not to say that a suppressor on a revolver wont reduce the decibel level, it's just not going to be a large amount. And it's not going to be close to the reduction you get with a gas seal revolver.
http://www.youtube.com/watch?v=vvF4yurWSc0