That's a big swing. The 2" barrel difference, nor the primer selection would cause such a variance. My first reaction would be to verify the Chronograph was set up properly [mine had the ability to change the distance of the screens. Generally, if things are off, I've placed them too far apart or close]. If the chrony is OK, I'd pull a bullet and reconfirm the weight of the charge. I checked the Hodgdon website, but they're not showing H4350 as a powder selected for the 55gr. It doesn't pop up until you get to the heavier bullets.
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