Been shooting Unique and only Unique in .45 Colt for 37+ years. My guns are mostly Rugers and I load heavier than 8.5gr as my standard load. No issues with consistency, I don't worry about extreme spread, its a PISTOL...
And, its a pistol I can ring the 200yd gong with, off hand, one handed, so I consider the consistency of my ammo sufficient. 250gr SWC at approx 1100fps from 7.5" barrel. have loaded heavier, choose not to.