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Originally Posted by mo84
once a person is hit with a bullet whither it be 22 or 500 mag, they are most likely not going to keep walking your way like they are the terminator or something. If they did for some chance keep walking after getting hit, a follow up shot should surely slow them down no matter the caliber.
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Uuuh, no. Handguns don't work like that. I've known folks who get wounded in a gunfight and don't even realize it for several minutes. When I got shot, I didn't know what had happened to me, I thought I had a bad charley-horse in my leg. All I knew is that my leg didn't work like it should, and I didn't understand why. Coupla minutes later: Oh, bullet hole. That explains it. Take me to a hospital.
Without getting into all the "why's" about caliber, larger is generally better. What most folks do is try to balance cartridge size with handgun size, something they can conceal easily.