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Yac, one of my all time favorite powders for the big straight wall pistol cases like 45 Colt and 44 Mag is Green Dot for plinking loads - lots of cowboy data available, just look on the Alliant web site. It's bulkier than some other powders so takes up a little more of the case. Watch out you do not double charge any cases. Provided your throats are properly dimensioned, i.e., not under sized, they should handle the lead loads just fine. Take the cylinder out and try a push thru to see with one of those .451 - quick way to check throat diameter. If they won't go thru (thumb push fit) you may not get any kind of accuracy as the bullet will get swaged smaller than the groove. The one 45 Colt pistol I have, I had to ream the throats. I've shot alot of 200 grainers in 45 Colt and they work fine. sundog
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safety first
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