That's a cool project.
I had a .458 Win Model 70 (I kick myself for selling  ) that I used to load 405 grain 45/70 lead bullet reduced loads.
I remember the powder was IMR 3031 and about 30 or 40 grains behind the big slug. I also put Dacron pillow stuffing on top of the powder to keep it against the flash hole. The result was one hole groups at 50 yards using the iron sights on the African. 
Great job and good luck on your further experiments! 
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