I have only messed with blue dot and reduced velocity .223 loads with 40 grain bullets. Back when .22LR rounds were made from unobtanium, I still wanted to squirrel hunt (and have something left to eat). A blue dot loaded 40 grain bullet at about 1000 fps fit that bill just fine.
I have heard rumors of folks messing with other pistol powders in rifles, but I have had no need.
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"The day you stop learning SHOULD directly coincide with the day you stop breathing."
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