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I don't have a chronograph but from some internet digging it looks to be about 1150-1200 fps out of a 4 inch.
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I got 1381 and 1403 with the Buffalo Bore heavy 180 grain Outdoorsman round out of a 4" Ruger Security six, so you should be able to get that with the GP100. That equals 783 foot pounds muzzle energy!
Should be ample for black bear and mountain lions with the flat point keith hard case bullets.
The eagle .357 is light to midrange stuff more in the 400 foot pound range.
(BB chart says that 158 grain @ 1100 Fps = 424 ft # ME.)