While no opinion on your choice, caliber wise I concur with all above on the 6.5.
I hunted Caribou with a 7mm. Somewhat bigger than a deer, all shots went through some far side shoulder.
As it had not fully expanded I was lucky and able to salvage most of the meat for stew.
The 7mm had to do with moose possibility as well as dealing withe bears.
270 would have been my choice for just Caribou, that was before the 6.5s had established themselves.
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