From personal experience I would get the .45Colt. Very nice and easy shooting with plenty of knock down for a 100 yard shot. Especially if you can get some hot loads for it. You could also then get you a single action revolver in the same caliber and be good to go.
If you've never shot the .45Colt give it a try and you will be pleasently surprised.
I got the Trails End model in October and with 11+1 capacity it is very nice. Groups well also.
If you are leaning towards a revolver in .357 then I would certainly go with that caliber as to have a matching set.
best of luck,
sks
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