Almost every self defense situation is short range. So, I wouldn't use a high powered rifle. I think, just rifle cartridges, the 7.62x39 and 45-70 could be decent choices. But only with either hollow points or ballistic tips. I'd rather use handgun catridges in a rifle though for self defense if I had the choice.
As far as actions are concerned, I think semi auto would be best but a pump would work good too. Revolving rifles could do the job well too. But I wouldn't want to use a bolt action or a single shot.
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