I haven't shot any of the big bore Handi's but my friends heavy barreled .223 with 3-12x42 Nikon will make cloverleafs at 100 yards. His 52g bthp handloads are sub .5 MOA.
He shoots golf balls at 100 yards.
I've often though about Chambering one for 7.62x39 or 300 blackout and running subsonics for pest control.
Boomer
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