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Game animals are killed with bullets. Cartridges shoot bullets. Rifles direct them.
Same bullet at given speed, impact point and angle into the animal will perform identical regardless of what shot them.
If you insist on using a cartridge to kill an animal, use a 40mm Bofors heavy machine gun round swinging it like a baseball bat smacking the big animal up side its head with the heavy projectile. Or try stabbing it with a 50 caliber BMG round.
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