From Hodgdon's website -
Reduce H110 and Winchester 296 loads 3% and work up from there. H110 and Winchester 296 if reduced too much will cause inconsistent ignition. In some cases it will lodge a bullet in the barrel, causing a hazardous situation (Barrel Obstruction). This may cause severe personal injury or death to users or bystanders. DO NOT REDUCE H110 LOADS BY MORE THAN 3%.
It just doesn't work as well as some other powders when reduced loads are used. (Don't look for consistency in
all things related to reloading...
)
I use W231 for lighter loads in .44 Magnum, but this may be too far in the "powder puff" direction for what you are trying to accomplish. While I have no experience with it, Alliant 2400 is supposed to like reduced loads better than H110/W296.