Scopes are better, plain and simple, close to far, slow moving or fast, thick cover or wide open fields. Not saying that you're not gonna have trouble seeing/hitting a running deer at 50 feet with the over sized, overweight, large scopes in vogue today but keep the magnification and size modest and they're better any day of the week and twice on Sunday's.
I do however occasionally hunt with a 10/22 using factory open sights and scopes on handguns turn my stomach so any hunting with them is using open sights. Other than that if it can where a scope it does where a scope.
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