I would never do it or recommend it, and I think it's unethical, but I had a buddy who's dead now that once shot a little doe in the neck with a .17 HMR from a T/C contender- he said she dropped instantly and didn't move.
Personally, on these smallish southern deer, I do think .223 is ethical if you wait for the right shot and don't try to shoot through a shoulder/leg bone, and use the correct bullet type. I personally would not go below .223 rem, though.
If I were hunting up north (IA/NE/North. MO/IL/IN and points northward), I wouldn't go below .243 win, .30-30, .44 mag, 7.62x39, 6.8 SPC, or 6.5 grendel for whitetails or mulies.
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