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It may well.... but the force level of a 385gr 12ga slug fired at 1900fps from a distance of 40 yards or less is near the top of the pile in "knockdown power". The only deer I've EVER hit that fell DRT were hit in the neck, not the spine in particular, but the neck.
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Well, I'll grant you that a 12 gauge slug has a lot going for it, but it's basically a large caliber punch press. It'll penetrate large critters as easily as small ones, but it doesn't carry much "shock" when it hits. It simply punches a big hole.
A 100 grain .243 bullet at 3150-3250 FPS at the muzzle usually drops them in their tracks out to 300 yards. A 145 grain 7mm bullet at 3150 fps at the muzzle does the same thing at 500 yards. Or, that's been my experience.
Depending on the bullet used, of course, but that's another debate I suppose.
The neck shot is certainly effective, but I can only remember doing it once. I had a choice between that and a "Texas heart shot" on a coues deer buck at ~10 yards with a 7mm mag, and took the neck shot. Usually, I aim for the chest.
Daryl