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If you're going to carry big iron for self defense rather than the lighter 327 MAG revolvers that are available, might as well be chambered for 357 MAG.
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Why stop the bigotry there? If you're going to carry "big iron" a .44 Mag or .454 Casul is better than the .357 MAG.
Ballistics on the .327 overlap a good portion of the .357 Magnum so you're not giving up very much to the small bore.