You will probly find no difference, but as you said, start low and work up. A few years back I got a wild hair and and loaded several different rounds with everything the same except the primer. I found that in most cases there was no difference in velocity. I did find that with 1 load that there was signs of pressure with 1 primer, that that was with a standard primer and not a mag. primer, so there are some small differences.
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