With proper shot selection, good bullets and bullet placement, the .270 Win is adecuate for anything that walks North America. Though I'd deffinatly want something larger on the griz variety of bruin... Just in case. The rest - I've already taken with mine, excepting Caribou which I doubt would be hardier than Moose! It's always functioned just fine.
But, that being said, if you are willing to settle for less than ideal bullet placement, plan to take running shots, or just have trouble keeping groups small enough to hit the vitals at hunting ranges - take something larger with more power. Then the answer is "No. It is not adecuate to take big game." But than again, given such circumstances, neither is a .460 Wetherby.